亚博appjinri，yixuebulvdeshengjiaoshoutuanduihehuaxueyuanzhangpingyulaoshihezuozaiguojidingjixueshuqikan《angewandte chemie-international edition》（jcr1qutop,yingxiangyinzi:
12.959）fabiaotiwei《sulfur-coordinated organoiridium(iii) complexes exert anti-breast cancer activity via inhibiting wnt/β-catenin signaling》dewenzhang。zheipianwenzhangdesuoyougongzuojunzaiyaboappwancheng，yixuebusunqijiangshishizheipianwenzhangdediyizuozhe，lvdeshengjiaoshouhezhangpingyuzhulijiaoshouweigongtongtongxunzuozhe，yaboappweidiyiwanchengdanwei。
亚博appruxianaishizuichangjiandeexingzhongliu，yeshiquanqiunvxingaizhengsiwangdedierdayuanyin。suiranxianjindezhiliaofanganxianzhutigaoleruxianaihuanzhedezhengtishengcunlv，danrengyou20%-30%dehuanzhefufa，60%defufahuanzhezhuanyi。yuelaiyueduodezhengjubiaoming，zhongliuganxibaodecunzaishiruxianaifufahezhuanyidezhuyaoyuanyin。wnt/β-cateninshishengwujinhuazhonggaodubaoshoudexinhaotonglu，zaishengwutifayu、ganxibaogongnenghezuzhiwentaizhongqizhezhongyaozuoyong。wntxinhaotongludeyichangjihuoyuzhongliuganxibaodeweichiheduozhongzhongliudefashengfazhanmiqiexiangguan，baokuoruxianai。yinci，fazhanzhenduiwntxinhaotongluhezhongliuganxibaodebaxiangliaofajianghuiweiruxianaidezhiliaodailaixinxiwang。
图1.A.金属铱配合物B.含硫金属铱配合物能够通过靶向作用于Wnt/β-catenin信号通路的Wnt共受体LRP6对乳腺癌的发生发展及乳腺癌干性产生抑制作用
jinshukangaiyaowushunboshizhiliaogezhongzhongliuzhongzuiweiguangfanshiyongdehualiaoyaowuzhiyi,raner，qilinchuangliaoxiaozaihendachengdushangshoudaonaiyaojiqifuzuoyongdexianzhi。linchuangshangjidaifazhangengyouxiaodezhenduizhongliuteyibadiandejinshuleiyaowu，qijin，renmenduijinshuleikangzhongliuyaowuzaizhongliuganxibaojiqizhongliuganxibaoxiangguanxinhaotongluzhongdezuoyongzhizhishenshao。
亚博appbenyanjiushejihechengleyixiliejinshuyipeihewu，genjuqijiegouhuoxingxiangguanxingfenxijishiyanyanjiu，faxianliangzhonghanliujinshuyipeihewunenggoutongguobaxiangzuoyongyuwnt/β-cateninxinhaotongluzhongdewntgongshoutilrp6，cujinqineihua，bingjingguorongmeititujingjiangjie，gaiguochengyouxiaojiangdilexibaozhongdvl2、β-cateninhehuohuaβ-catenindedanbaibiaoda，daozhiyuruxianaiganxingxiangguandewntbajiyincd44hesurvivindexiadiao，jineryizhiruxianaixibaodezengzhi、qianyiheqinxi，bingyoudaoqidiaowang。zairuxianaixiaoshuyizhongyizhimoxingheruxianaifeizhuanyimoxingzhong，yuchuantongdejinshuyaowushunboxiangbi，hanliujinshuyipeihewutongguobaxiangwnt/β-cateninxinhaotonglu，biaoxianchugengqiangdejiekangruxianaiheruxianaiganxibaodehuoxing。
亚博appgaixianggongzuobiaoming:
hanliujinshuyipeihewutongguobaxiangwnt/β-catenintonglu，juyouqianzaidekangruxianzhongliuheruxianaiganxibaodenengli，gaiyanjiujieshilejinshuleikangzhongliuyaowudeqianzaixinbadian，bingweixinyingjinshuleikangzhongliuyaowudeyanfakaipilexindesilu。
图2.与传统的金属药物顺铂相比含硫金属铱配合物能够显著抑制乳腺癌的肺部转移
